报告题目：LINC00673 Germline Variant Confers Susceptibility to Pancreatic Cancer through Attenuated Interaction with SHP2 induced by inhibition of miR-1231
报告人：郑健博士
报告时间：2015年4月2日（周四）下午14：00
报告地点：新威尼斯v0008独墅湖校区医学楼403-3120
报告人简介：
2012年7月毕业于新威尼斯v0008，获得硕士学位，同年9月考入中国医学科学院/北京协和医学院，将于2015年7月获得博士学位。硕士和博士期间研究领域均为肿瘤遗传学，主要探讨非编码RNA (microRNA、LincRNA) 在肿瘤发生、发展中的作用机制。至2015年，已在SCI杂志发表论文29篇，总I.F.超过140。第一作者11篇 (总I.F.超过70)：包括“Gastroenterology (I.F. 13.93)”、“Cancer Research” (I.F. 9.28)、“Oncogene” (I.F. 8.56)、“Carcinogenesis” (I.F. 5.27)、“International Journal of Cancer” (I.F. 5.07) 和“Human Mutation” (I.F. 5.05) 等；个人H因子12 (H-index)。
近三年发表的论文：
1. Wu H*, Zheng J*, Deng J, Zhang L, Li N, Li W, Li F, Lu J, Zhou Y. LincRNA-uc002yug.2 involves in alternative splicing of RUNX1 and serves as a predictor for esophageal cancer and prognosis. Oncogene. 2014 Dec 8. [Epub ahead of print]
2. Li W*, Zheng J*, Deng J, You Y, Wu H, Li N, Lu J, Zhou Y. Increased levels of the long noncoding RNA POU3F3 promote DNA methylation in esophageal squamous cell carcinoma cells. Gastroenterology. 146(7):1714-26; 2014.
3. Zheng J, Deng J, Xiao M, Yang L, Zhang L, You Y, Hu M, Li N, Wu H, Li W, Lu J, Zhou Y. A sequence polymorphism in miR-608 predicts recurrence after radiotherapy for nasopharyngeal carcinoma. Cancer Res.73(16):5151-62; 2013.
4. Zheng J, Deng J, Jiang L, Yang L, You Y, Hu M, Li N, Wu H, Li W, Li H, Lu J, Zhou Y. Heterozygous genetic variations of FOXP3 in Xp11.23 elevate breast cancer risk in Chinese population via skewed X-chromosome inactivation. Hum Mutat. 34(4):619-28; 2013. (IF: 5.05)
5. Zheng J, Jiang L, Zhang L, Yang L, Deng J, You Y, Li N, Wu H, Li W, Lu J, Zhou Y. Functional genetic variations in the IL-23 receptor gene are associated with risk of breast, lung and nasopharyngeal cancer in Chinese populations. Carcinogenesis. 33(12):2409-16; 2012.
6. Zheng J, Liu B, Zhang L, Jiang L, Huang B, You Y, Jiang Q, Zhang S, Lu J, Zhou Y. The protective role of polymorphism MKK4-1304 T>G in nasopharyngeal carcinoma is modulated by Epstein-Barr virus' infection status. Int J Cancer. 130(9):1981-90; 2012.
报告题目:Exploring Lipid Functions in Animals
报告人:Dr. Huanhu Zhu
报告时间：2015年4月2日（周四）下午14：00
报告地点：新威尼斯v0008独墅湖校区医学楼403-3120
报告人简介：
Dr. Zhu received his Ph.D. at Fudan University and now is a postdoctoral research associate at Howard Hughes Medical Institute/ University of Colorado at Boulder. He is working on functional study of branched chain fatty acid, sphingolipid and related signaling pathways by using Nematode C. elegans.
Recent publications:
1.H Zhu, AK Sewell, and M Han.
Glucosylceramide activates TORC1 pathway via endocytosis to promote postembryonic development in Caenorhabditis elegans. Submitted.
2.M Kniazeva, H Zhu and M Han
A lipid-TORC1 pathway promotes neuronal development and functions involved in food responses in C. elegans. Developmental Cell, in press.
3.H Zhu and M Han
Exploring developmental and physiological functions of fatty acid and lipid variants through worm and fly genetics. Annual Review of Genetics, 2014;48:119-48. doi: 10.1146/annurev-genet-041814-095928. Epub 2014 Aug 25.
4.J Ren, H Zhu, C Chi, M Mehrmohamadi, K Deng, X Wu, T Xu.
Beadex affects gastric emptying in Drosophila. Cell Res. 2014 May;24(5):636-9. doi: 10.1038/cr.2014.24.
5.H Zhu, HShen, AK Sewell, M Kniazeva, M Han.
A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans. eLife. 2013 May 21;2:e00429.