The Secretory Pathway in Cholesterol Regulation: Roles of the COPII Complex

发布时间:2014-09-17浏览次数:853

嘉  宾:陈晓伟博士,博士生导师

        北京大学分子医学研究所分子代谢调控研究室主任

        北大清华生命科学联合中心研究员

题  目: The Secretory Pathway in Cholesterol Regulation: Roles of the COPII Complex

时  间:  2014年9月24日(周三)下午3:00-4:00

地  点:  新威尼斯v0008独墅湖校区403-3120,新威尼斯v0008学术活动室

邀请人: 生化与分子生物学系苏雄教授

演讲嘉宾简介:

陈晓伟博士2002年毕业于北京大学生物化学与细胞生物学系;2008年获美国密歇根大学博士;2014年起任北京大学北清联合中心和分子医学研究所教授。曾获密歇根大学Horace Davenport Research Award,国家优秀自费留学生奖,以及美国国立卫生院Earl Stadtman Scholar Program Finalist。 担任多种领域内主流学术期刊的审稿人。

陈晓伟教授的主要研究方向为small GTPase,exocyst, COPII等蛋白质转运和分泌通路分子在糖类和胆固醇代谢中的调控功能。近年代表性论文如下:

1. Chen XW, Wang H, Pahuja KB, Zhang P, Meng ZX, Ma D, Bai Y, Liu H, Adams E, Baines A, Yu G, Sartor MA, Zhang B, Yi Z, Young SG, Schekman R, and Ginsburg D. SEC24A Deficiency Lowers Plasma Cholesterol through Reduced PCSK9 Secretion. eLife 2013 Apr 9;2:e00444. (Editor’s choice; also commented by DeBose-Boyd and Horton; highlighted by Faculty of 1000)

2. Chen XW, Saltiel AR. Ral’s Engagement with the Exocyst: Breaking UP is Hard to Do. Cell Cycle 2011 Jul;10(14):2299-304.

3. Chen XW, Leto D, Xiao J, Goss J, Wang Q, Shavit JA, Xiong TT, Yu GG, Toomre D, Ginsburg D, Xu Z, and Saltiel AR. Exocyst Function is Regulated by Effector Phosphorylation. Nature Cell Biol. 2011 May; 13(5):580-8. (Highlighted by Faculty of 1000)

4. Chen XW, Leto D, Xiong TT, Yu GG, Decker SJ, and Saltiel AR. A Ral GAP Complex Links PI 3-Kinase/Akt Signaling to RalA Activation in Insulin Action. Mol. Biol. Cell 2011 Jan; 22 (1):141-52. (Editorial Highlighted Paper)

5. Chen XW, Leto D, Chiang SH, Wang Q, Saltiel AR. The Activation of RalA is Required for Insulin-Stimulated Glut4 Trafficking to the Plasma Membrane via the Exocyst and the Motor Protein Myo1c. Dev. Cell 2007 Sep; 13(3):391-404.

6. Chen XW, Inoue M, Hsu SC, Saliel AR. RalA-Exocyst Dependent Recycling Endosome Trafficking is Required for the Completion of Cytokinesis. J Biol. Chem. 2006 Dec 15; 281(50): 38609-16.