嘉宾：Yabing Chen, PhD / MBA
Department of Pathology, The University of Albama at Birmingham
题目：Hard Issues on Soft Tissues: Molecular Regulation of Vascular Calcification
时间：2014年6月16日（周一）上午9:00-9:30
地点：新威尼斯v0008独墅湖校区403号楼3119会议室
主持人：细胞生物学系 白艳艳副教授
演讲嘉宾简介：
Dr. Chen received her BS degree from Fudan University and her Ph.D. from Xiamen University. She completed postdoctoral training and was appointed as a research instructor at the University of Vermont, School of Medicine. Dr. Chen joined the faculty of Department of Pathology at UAB in June 2004. She is currently a tenured Associate Professor in Molecular and Cellular Pathology as well as a Principal Investigator at the Birmingham VA Medical Research Division. Dr. Chen serves as an editorial board member for Arteriosclerosis, Thrombosis and Vascular Biology (ATVB) and the Journal of Biological Chemistry (JBC). She is a Fellow of the American Heart Association (AHA) and a member of Committee for Scientific Sessions Planning (CSSP) Committee of the AHA/ATVB council. Dr. Chen has served the NIH Atherosclerosis and Inflammation of the Cardiovascular System (AICS) and Vascular cell and Molecular Biology (VCMB) study sections as an Ad Hoc reviewer in the past few years, and she is currently a regular member of the VCMB study section.
代表性作品：
Heath J, Sun Y, Yuan K, Bradley WE, Litovsky S, Dell'italia LJ, Chatham JC, Wu H, Chen Y*. Activation of AKT by O-GlcNAcylation Induces Vascular Calcification in Diabetes. Circ Res. 2014
Yuan K, Sun Y, Zhou T, McDonald JM, Chen Y*. PARP-1 Regulates Resistance of Pancreatic Cancer to TRAIL Therapy. Clin Cancer Res. 2013, 19(17):4750-9.
Sun Y, Byon CH, Yuan K, Chen J, Mao X, Heath JM, Javed A, Zhang K, Anderson PG, Chen Y*. Smooth muscle cell-specific runx2 deficiency inhibits vascular calcification. Circ Res. 2012 Aug 17;111(5):543-52.
Mao X, Debenedittis P, Sun Y, Chen J, Yuan K, Jiao K, Chen Y*. Vascular smooth muscle cell smad4 gene is important for mouse vascular development. Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2171-7.
Chen J, Sun Y, Mao X, Liu Q, Wu H, Chen Y*. RANKL up-regulates brain-type creatine kinase via poly(ADP-ribose) polymerase-1 during osteoclastogenesis. J Biol Chem. 2010 Nov 19;285(47):36315-21.
(* correspondence author)
嘉宾：Jiliang Zhou, MD / PhD
Department of Pharmacology & Toxicology, Medical College of Georgia, Georgia Regents University
题目：Role of Hippo-YAP signaling in smooth muscle phenotypic modulation and development
时间：2014年6月16日（周一）上午9:30-10:00
地点：新威尼斯v0008独墅湖校区403号楼3119会议室
主持人：细胞生物学系 白艳艳副教授
演讲嘉宾简介：
Dr. Zhou is an Associate Professor at Department of Pharmacology and Toxicology in Medical College of Georgia, Georgia Regents University. Research at Dr. Zhou’s laboratory focuses on smooth muscle phenotypic switch and development. Particularly, his group is studying the role of Hippo-YAP signaling in vascular smooth muscle cells by utilizing a variety of approaches including transgenic and tissue specific knock-out mice. His group has published many high quality papers in the journals such as Circ. Res., ATVB and JBC.
代表性作品：
Wang Y., Hu G., Liu F., Wang X., Wu M., Schwarz J., Zhou J.*. Deletion of Yes-Associated Protein (YAP) specifically in cardiac and vascular smooth muscle cells reveals a crucial role for YAP in mouse cardiovascular development. Circulation Research, 2014, 114(6): 957-965. Cover Article and Editor’s Picks. Liu F., Wang X., Hu G., Wang Y., and Zhou J.*. The transcription factor TEAD1 represses smooth muscle-specific gene expression by abolishing myocardin function. J. Biol. Chem., 2014, 289(6): 3308-3316. Selected as a “Paper of the Week” with the criteria that ranked in the top 2 percent of manuscripts in a year in significance and overall importance by the editorial board members and associate editors. Wang, X., Hu, G., Gao, X., Wang, Y., Zhang, W., Harmon, E. Y., Zhi, X., Z. Xu, Lennartz, M. R., Barroso, M., Trebak, M., Chen, C., and Zhou, J.*. The induction of Yes-Associated Protein expression after arterial injury is crucial for smooth muscle phenotypic modulation and neointima formation. Arteriosclerosis, Thrombosis, and Vascular Biology, 2012, 32(11): 2662-2669. Wang X., Hu G., Courtney B.C., Harmon, E.Y., Keller R.S., Van De Water L., and Zhou J.*. Transforming Growth Factor-β1-induced Transcript 1 protein, a novel marker for smooth muscle contractile phenotype, is regulated by serum response factor/myocardin protein. J. Biol. Chem., 2011, 286(48): 41589-41599. Zhou, J.*, Hu, G., Wang X.. Repression of smooth muscle differentiation by a novel high-mobility-group box containing protein, HMG2L1. J. Biol. Chem., 2010, 285(30): 23177-23185. Wang, X., Hu, G., Zhou, J.*. Repression of versican expression by miR-143. J. Biol. Chem., 2010, 285(30): 23241-23250.
(* correspondence author)
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