嘉宾：蒋羽 博士
美国匹兹堡大学Associate Professor（终身教授）
题目：Regulation of Mammalian Target of Rapamycin.
时间：2013年10月14日（周一）下午2:30-3:30
地点：403-3119会议室
演讲嘉宾简介：
蒋羽教授1985年毕业于四川大学遗传学系，1988年于中国科技大学分子生物学系获得硕士学位，1995年在美国耶鲁大学获得博士学位。之后在普林斯顿大学进行博士后课题研究。2000年起任美国匹兹堡大学药理学与化学生物学系Assistant Professor，Associate Professor (with tenure)。
蒋羽教授的主要研究方向为细胞生长和代谢调控的信号通路，先后在Nature，Science, PNAS，EMBO J等杂志上发表了三十多篇具有影响力的文章。
讲座的主要内容简介：
The mammalian target of rapamycin (mTOR) is a protein ser/thr kinase that plays a key role in translation, autophagy and mitochondrial biogenesis. Its activity is regulated by signals of various origins, including nutrient, growth factor, energy and stress. Dr. Jiang’s lab identified FKBP38 that acts as an inhibitor of mTOR and also found that FKBP38 is involved in recruitment of mTOR to mitochondria. Recently his lab works on the mechanism of FKBP38 in apoptosis regulation and the role of primary cilium in mTOR regulation. Their aims are to determine whether nutrient, growth factor and oxygen levels control the anti-apoptotic activity of Bcl-2 and Bcl-xL through FKBP38 and to explore the mechanisms through which primary cilium controls mTOR activity.