报告题目： L-型钙离子通道CaV1.2在心血管系统中的功能最优化研究
Optimization of L-type CaV1.2 calcium channel function in the cardiovascular system
报告人: Dr. Soong Tuck Wah (新加坡国立大学国家神经科学研究所)
报告时间: 2011年7月21日（周四）上午10：00
报告地点: 新威尼斯v0008神经科学研究所会议室
Soong Tuck Wah简介：
1983年本科毕业于新加坡国立大学获学士学位（荣誉学位），1992年于新加坡国立大学分子与细胞生物研究所（IMCB）获得博士学位（分子免疫）。1992年至1995年于加拿大University of British Columbia博士后研究（Prof Terry Snutch，世界钙通道命名者之一），1996年至1999年间任新加坡IMCB研究员，The Johns Hopkins University医学院讲座教授。1999年至今在新加坡国立大学国家神经科学研究所历任助理教授，副教授，教授。目前Soong Tuck Wah教授担任新加坡国立大学生理系主任，国家神经科学研究所首席研究员，新加坡神经科学会主席。 Prof. SOONG在SCIENCE, Nature, PNAS, J Neurosci, JBC等杂志发表论文数篇，并目前担任神经科学领域多个高影响杂志审稿人及编委。实验室目前研究方向为：L-型钙离子通道在神经及心血管疾病中的病理生理调节。
Selected Publications:
Soong T W, A. Stea, C. D. Hodson, S. J. Dubel, S. R. Vincent, and T. P.Snutch.
Structure and Functional Expression of a Member of the Low Voltage-activated Calcium Channel Family. Science, (1993) 260: 1133-1136.
Stea A, Soong TW, and Snutch TP. Determination of PKC-dependent modulation of a family of neuronal calcium channels. Neuron, (1995),15: 929-940.
Soong TW*, E. Bourinet*, K. Sutton, S. Slaymaker, E.Mathews, A. Monteil, G. W. Zamponi, J. Nargoet, and T.P. Snutch. Splicing of 1A subunit gene generates phenotypic variants of P- and Q-type calcium channels. Nat. Neurosci. (1999) 2: 407-415.
DeMaria CD, Soong TW, Alseikhan BA, Alvania RS, and Yue DT. Calmodulin bifurcates the local Ca2+ signal that modulates P/Q-type Ca2+ channels. Nature, (2001); 411: 484-489.
Chaudhuri D, Chang SY, Demaria CD, Alvania RS, Yue DT, Soong TW. Splice variation functions as a molecular switch for Ca2+/calmodulin-dependent facilitation of P/Q-type Ca2+ channels. J Neurosci., 2004, 24(28):6334-6342.
Tang ZZ, Liang MC, Lu SQ, Yu D, Yu CY, Yue DT and Soong TW. Transcript-scanning reveals Novel and Extensive Splice Variations in Human L-type Voltage-gated Calcium Channel, Cav1.2 ?1-subunit. J. Biol Chem, 2004, 43: 44335-44343
Liao P, YuD, Lu SQ, Tang ZZ, Liang MC, Zeng S, Lim W, and Soong TW. Smooth muscle selective alternatively spliced exon generates functional variation in Cav1.2 calcium channels. J. Biol Chem, 2004, 48:50329-5033.
Liao P, Yong TF, Liang MC, Yue DT, Soong TW. Splicing for alternative structures of Cav1.2 Ca2+ channels in cardiac and smooth muscles. Cardiovasc Res. 2005, 68(2):197-203.
Venkatesh B, Lu SQ, Dandona N, See SL, Brenner S, Soong TW. Genetic basis of tetrodotoxin resistance in pufferfishes. Curr Biol. 2005;15(22):2069-72.
Y Shen, D Yu, H Hiel, P Liao, DT Yue , PA Fuchs, and TW Soong. Alternative splicing of the CaV1.3 channel IQ domain-a molecular switch for Ca2+-dependent inactivation within auditory hair cells. J Neurosci. 2006, 26(42):10690-9.
Soong TW and Venkatesh B. Adaptive evolution of tetrodotoxin resistance in animals. Trends Genet. 2006 Nov;22(11):621-6. Epub 2006 Sep 7.
Tao J, Liang MC, Hildebrand ME, Tan G, Shen Y, Li S, Snutch, TP and Soong TW. Activation of corticotrophin-releasing factor receptor 1 selectively inhibits Cav3.2 T-type calcium channels. Mol Pharmacol, Jun 2008, 73(6): 1596-1609
Liao P, Yu D, Li G, Yong TF, Soon JL, Chua YL and Soong TW. A smooth muscle Cav1.2 calcium channel splice variant underlies hyperpolarized window current and enhanced state-dependent inhibition by nifedipine. J. Biol Chem, . 2007 Nov 30, 282:35133-42
H Huang, BZ Tan, Y Shen, J Tao, F Jiang, YY Sung, CK Ng, M Raida, G, Köhr, M Higuchi H Fatemi-Shariatpanahi, DT Yue and TW Soong. RNA editing of the IQ domain in Cav1.3 channels modulates their Ca2+-dependent inactivation. PNAS, 2011, Accepted