报告题目：极端环境下的基因组进化
报告人: 陈 良 标 博士
报告时间: 2011年5月30日 9:30 AM
报告地点: 新威尼斯v0008独墅湖校区403楼3119会议室
陈良标博士简介
陈良标，男，中国科学院遗传与发育生物学研究所研究员，博士生导师，中科院百人计划、国家杰出青年基金获得者。
1984-1988杭州大学生物系细胞生物学专业, 学士学位。
1988-1991中国科学院发育生物学研究所, 硕士学位。
1991-1996美国University of Illinois at Urbana-Champaign, 分子生理学博士学位。
1997-1999美国National Institutes of Health, 博士后。
2000-2001美国生物信息公司Doubletwist Inc.，数据库工程师。
2001-2002浙江大学生命科学院,教授。
2003-至今，中科院遗传与发育生物学研究所，研究员。
2004年入选中科院'百人计划'。
2006年获国家杰出青年基金。
陈良标博士目前主要研究方向为进化基因组学、生物信息及干细胞。近年来以项目主持人身份获得了包括国家杰出青年基金、国家自然科学基金重点项目、国家自然科学基金重大国际合作项目、973、863、国家转基因重大专项、国家自然科学基金面上项目在内的超过1300万元的项目资助。在Nature, Proc Natl Acad Sci U S A, Mol. Biol. Evol. , FEBS Letters, Evolution and Development等国际知名杂志上发表了数十篇论文。
主要代表论文：
1.Deng C, Cheng CH, Ye H, He X, Chen L. (2010). Evolution of an antifreeze protein by neofunctionalization under escape from adaptive conflict. Proc Natl Acad Sci U S A. 107(50):21593-8.
2.Dai Z., Chen Z., Hua Y., Wang Y., Peng S. and Chen L. (2009). Characterization of microRNAs in cephalochordates reveals a correlation between miRNA repertoire homology and morphological similarity in chordate evolution. Evolution and Development. 11(1) 41-49.
3.Chen Z, Cheng CH, Zhang J, Cao L, Chen L, Zhou L, Jin Y, Ye H, Deng C, Dai Z, Xu Q, Hu P, Sun S, Shen Y, and Chen L. (2008). Transcriptomic and genomic evolution under constant cold in Antarctic notothenioid fishes. Proc. Natl. Acad. Sci. USA. 105:12944-12949.
4.Zhang J, Dend C, Wang J. and Chen L. (2008). Characterization of a two-domain antifreeze protein gene in Antarctic eelpout Lycodichthyus dearborni. Polar Biol. DOI 10.1007/s00300-008-0499-8.
5.Xu Q*, Cheng CH*, Hu P* (* co-first authors) , Ye H, Chen Z, Cao L, Chen L, Shen Y, Chen L. (2008). Adaptive evolution of hepcidin genes in antarctic notothenioid fishes. Mol. Biol. Evol. 25(6):1099-112.
6.Zuozhou Chen, Weilin Wang, Xuefeng Bruce Ling, Jane Jijun Liu and Liangbiao Chen (2006). GO-Diff: Mining functional differentiation between EST-based transcriptomes. BMC Bioinformatics 2006, 7:72
7.Lei Chen, Lixue Cao, Longhai Zhou, Yudong Jing, Zuozhou Chen,Cheng Deng, Yu Shen, Liangbiao Chen. Trehalose as a good candidate for enriching full-length cDNAs in cDNA library construction. Journal of Biotechnology. 2007, 127: 402–407
8.Hao Chen, Sheng Zhu, Liangbiao Chen (2005) Comparative analysis of internal repeating segments in proteins of species from the three kingdoms of life. Journal Genetics and Genomics 32(3):315-21
9.Zuozhou Chen, Chenghai Xue, Sheng Zhu, Fengfeng Zhou, Xuefeng Bruce Ling, Guoping Liu, Liangbiao Chen (2005). GoPipe: Streamlined Gene Ontology Annotation for Batch Anonymous Sequences with Statistics. Prog. Biochem. Biophys. 32(2): 187-191.
10.Sihua Peng, Qianghua Xu, Xuefeng Bruce Ling, Xiaoning Peng, Wei Du, Liangbiao Chen (2003). Molecular classification of cancer types from microarray data using the combination of Genetic Algorithms and Support Vector Machines. FEBS Letters, 555:358-62.
11.Chi-Hing C. Cheng and Liangbiao Chen. Evolution of Antifreeze Glycoprotein. Nature. 1999, 401:443-444.
12.Liangbiao Chen, Arthur L. DeVries, Chi-Hing C. Cheng. Evolution of antifreeze glycoprotein gene from a trypsinogen gene in Antarctic notothenioid fish. Proc. Natl. Acad. Sci. USA. 1997, 94:3811-3816.
13.Liangbiao Chen, Arthur L. DeVries, Chi-Hing C. Cheng. Convergent evolution of antifreeze glycoproteins in Antarctic notothenioid fish and Arctic cod. Proc. Natl. Acad. Sci. USA. 1997, 94:3817-3822.
14.SH Hahm, Liangbiao Chen, C Patel, J Erickson, TI Bonner, Eberhard Weihe, K. –H. Schafer, Lee E. Eiden. Upstream sequencing and functional characterization of the human cholinergic gene locus. Journal of Molecular Neuroscience. 1998, 9(3): 223-236.
15.Berkhard Schutz, Liangbiao Chen, K. –H. Schafer, Eberhard Weihe, Lee E. Eiden. Somatomotor neuron-specific expression of the cholinergic gene locus in transgenic mice. Neuroscience. 2000, 96(4): 707-722