报告题目： Ceramide Glycosylation Regulates the Expression of MDR1 and Mutant p53 in Cancer
报告人：刘永玉博士
报告时间：2011年1月6日（周四）下午2：00
报告地点：新威尼斯v0008独墅湖校区医学楼403-3119室
报告人简介：
Professional Appointment:
2006 – present
Assistant Professor of Pharmacology, Dept. Basic Pharmaceutical Sciences，University of Louisiana at Monroe, Louisiana
2007 – present
Adjunct Assistant Professor，Department of Medicine， Tulane University School of Medicine, Louisiana
2008 – present
Adjunct Assistant Professor，Division of Biotechnology and Molecular Medicine，LSU School of Veterinary Medicine, Louisiana
Publications:
1. Liu, Y.Y.*, Patwardhan, G.A., Bhinge, K., Gupta, V., Gu, X., Jazwinski, S.M., 20010. Suppression of glucosylceramide synthase restores p53-dependent apoptosis in mutant p53 cancer cells. Cancer Res. (accepted)
2. Patwardhan, G.A., Liu, Y.Y.* 20011. Sphingolipid and the regulation of gene expression in cancer. Prog. Lipid Res. 50:104-114
3. Liu, Y.Y.* 2010. The application of microarray in drug discovery. Modern Pharmacological Methods (book, in press)
4. Gupta, V., Qian-Jin Zhang and Liu, Y.Y.* 2010. Evaluate anticancer agents using flow cytometry analysis of cancer stem cells. Methods Mol Biol. (in press)
5. Wang, F., Liu, J., Robbins, D., Morris, K., Sit, A., Liu, Y.Y., Zhao, Y. 2010. Mutant p53 translocates into mitochondria with trivial effects on mitochondrial functions which can be reactivated by ellipticine in lymphoma cells. PLoS One (accepted)
6. Siddiqui, A., Patwardhan, G.A., Liu, Y.Y., and Nazzal, S. 2010. Mixed backbone antisense glucosylceramide synthase oligonucleotide (MBO-asGCS) loaded solid lipid nanoparticles: in vitro characterization and reversal of multidrug resistance in NCI/ADR-RES cells. Int J Pharm (accepted)
7. Chapman, J.V., Gouaze-Anderson, V., Messner, M., Flowers, M., Karimi, R., Kester, M., Barth, B.M., Liu, X., Liu, Y.Y., Giuliano, A.E., Cabot, M.C. 2010. Metabolism of short-chain ceramide by human cancer cells-implications for therapeutic approaches. Biochem. Pharmcol. 80:308-315
8. Liu, Y.Y.*, Gupta, V., Patwardhan, G.A., Yin, D., Bhinge, K., Zhao, Y., Bao, J., Mehendale, H., Cabot, M.C., Li, Y., and Jazwinski, S.M. 2010. Glucosylceramide Synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling. Mol Cancer 9(1):145 (featured Highly accessed)
9. Patwardhan, G.A., Gupta, V., Huang, J., Gu, X., Liu, Y.Y.* 2010. Direct assessment of P-glycoprotein to determine tumor response to chemotherapy. Biochem. Pharmcol. 80:72-79
10. Gupta, V., Patwardhan, G.A., Zhang, Q., Senkal, C.E., Ogretmen, B., Cabot, M.C., Jazwinski, S.M., and Liu, Y.Y.* 2010. Direct quantitation of ceramide glycosylation in cells: a new approach to evaluate the enzyme activity of glucosylceramide synthase. J. Lipid Res 51:866-874 (highlighted in ASBMB Today).
11. Patwardhan, G.A., Zhang, Q., Yin, D., Gupta, V., Bao, J., Senkal, C.E., Ogretmen, B., Cabot, M.C., Jazwinski, S.M., Liu, Y.Y.* 2009. A new mixed-backbone oligonucleotide targeting GCS sensitizes multidrug-resistant tumors to apoptosis. PLoS One 4(9):e6938
12. Li, X., Liu, Y.Y., Knight, D., Odaka, Y., Shi, R., Glass, J., Mathis, J.M., Zhang, J. 2009. Effect of B7.1 costimulation on T-cell based immunity against TAP-negative cancer can be facilitated by TAP1 expression. PLoS One 4(7):e6385.
13. Li, X, Zhang, D., Wang, D., Knight, D. Yin, L. Bao, J., Liu, Y.Y., Mathis, J.M., Shi, R., Glass, J. and Zhang, J. 2008. In vivo survivors of transformed mouse ovarian surface epithelial cells display diverse phenotypes for gene expression and tumorigenicity. Tumor Biol 29:359-370
14. Wang, H., Maurer, B.J., Liu, Y.Y., Wang, E., Allegood, J.C., Kelly, S., Symolon, H., Liu, Y., Merrill Jr., A.H., Gouaze-andersson, V., Yu, J.Y., Giuliano, A.E., and Cabot, M.C. 2008. N-(4-hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing. Mol Cancer Ther 7(9):2967-2976
15. Liu, Y.Y.*, Yu, J.Y., Yin, D., Patwardhan, G., Gupta, V., Hirabayashi, Y., Holleran, W. M., Jazwinski, S. M., Giuliano, A. E., Gouaze-Andersson, V., Consoli, D. P., Cabot, M. C. 2008. A role of ceramide in driving cancer cell resistance to doxorubicin. FASEB J. 22, 2541-2551 (cited more than 24 by others)