报告题目：A novel transcriptional factor kruppel zinc finger protein modulates ventral posterior patterning via wnt8
报告人: 莫显明教授
报告时间: 2010年11月5日上午9:30-10:30
报告地点: 新威尼斯v0008独墅湖校区炳麟图书馆825会议室
莫显明教授简介：
莫显明, 四川大学华西临床医学院，华西医院教授。莫显明1991年在华西医科大学获得病理学专业医学硕士学位；1994年在北京协和医科大学获得生物化学与分子生物学专业医学博士学位。先后在德国洪堡大学Franz-Volhard医院和美国佐治亚医学院分子医学与遗传学研究所作博士后。曾任美国佐治亚医学院医学系助理科学家，德国Max-Delbruck分子医学中心高级科学家和博士生指导教师。2006以来在四川大学华西临床医学院华西医院干细胞生物学研究室，从事干细胞生物学与组织发生，以及干细胞性疾病发病机理, 诊断与治疗的研究。已在国际著名杂志Molecular Cell， Gene& Development，PNAS, Oncogene，Leukimia， Molecular and cellular Biology， Human Molecular Genetics ，JBC等发表20多篇论文。获得教育部“新世纪优秀人才支持计划”和自然科学基金面上项目资助，并主持科技部973项目子课题两项。
主要代表论文：
1.Chen T, Dong B, Lu Z, Tian B, Zhang J, Zhou J, Wu H, Zhang Y, Wu J, Lin P, Zhang J, Xu H, Mo X. A functional single nucleotide polymorphism in promoter of ATM is associated with longevity. Mech Ageing Dev. 2010 Oct;131(10):636-40. Epub 2010 Sep 15.
2. Li Y, Wang WJ, Cao H, Lu J, Wu C, Hu FY, Guo J, Zhao L, Yang F, Zhang YX, Li W, Zheng GY, Cui H, Chen X, Zhu Z, He H, Dong B, Mo X, Zeng Y, Tian XL. Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations. Hum Mol Genet. 2009 Dec 15;18(24):4897-904. Epub 2009 Sep 29.
3. Lu Z, Dong B, Mo X, Chen T, Wu H, Zhang Y, Xiao H. Pro12Ala polymorphism in PPAR gamma 2 associated with essential hypertension in Chinese nonagenarians/centenarians. Exp Gerontol. 2008 Dec;43(12):1108-13. Epub 2008 Aug 26.
4. Lin YF, Jing W, Wu L, Li XY, Wu Y, Liu L, Tang W, Long J, Tian WD, Mo X. Identification of osteo-adipo progenitor cells in fat tissue. Cell Prolif. 2008 Oct;41(5):803-12.
5. Yao S, Xie L, Qian M, Yang H, Zhou L, Zhou Q, Yan F, Gou L, Wei Y, Zhao X, Mo X. Pnas4 is a novel regulator for convergence and extension during vertebrate gastrulation. FEBS Lett. 2008 Jun 25;582(15):2325-32. Epub 2008 Jun 4.
6. Zhao S, Tang QL, He MX, Yang F, Wang H, Zhang WY, Jiang W, Wang XL, Mo X, Li GD, Liu WP. A novel nude mice model of human extranodal nasal type NK/T-cell lymphoma. Leukemia. 2008 Jan;22(1):170-8. Epub 2007 Sep 13.
7. Chen Y, Xu H, Liu J, Zhang C, Leutz A, Mo X. The c-Myb functions as a downstream target of PDGF-mediated survival signal in vascular smooth muscle cells. Biochem Biophys Res Commun. 2007 Aug 24;360(2):433-6. Epub 2007 Jun 21.
8. Mo X, Kowenz-Leutz E, Laumonnier Y, Xu H, Leutz A. Histone H3 tail positioning and acetylation by the c-Myb but not the v-Myb DNA-binding SANT domain. Genes Dev. 2005 Oct 15;19(20):2447-57. Epub 2005 Sep 29.
9. Hu WH, Pendergast JS, Mo X, Brambilla R, Bracchi-Ricard V, Li F, Walters WM, Blits B, He L, Schaal SM, Bethea JR. NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation. J Biol Chem. 2005 Aug 12;280(32):29233-41. Epub 2005 Jun 10.
10. Hu WH, Mo X, Walters WM, Brambilla R, Bethea JR. TNAP, a novel repressor of NF-kappaB-inducing kinase, suppresses NF-kappaB activation. J Biol Chem. 2004 Aug 20;279(34):35975-83. Epub 2004 Jun 18.
11. Rushton JJ, Davis LM, Lei WL, Mo XM, Leutz A, Ness SA. Distinct changes in gene expression induced by A-Myb, B-Myb and c-Myb proteins. ONCOGENE 卷: 22 期: 2 页: 308-313。
12. Mo X, Kowenz-Leutz E, Xu H, Leutz A. Ras induces mediator complex exchange on C/EBP beta. Mol Cell. 2004 Jan 30;13(2):241-50.
13. Mo, XM; Dynan, WS. Subnuclear localization of Ku protein: Functional association with RNA polymerase II elongation sites. MOLECULAR AND CELLULAR BIOLOGY 卷: 22 期: 22 页: 8088-8099.
14. Mo, XM; Bailin, T; Sadofsky, MJ. A C-terminal region of RAG1 contacts the coding DNA during V(D)J recombination. MOLECULAR AND CELLULAR BIOLOGY 卷: 21 期: 6 页: 2038-2047
15. Mo XM, Tu BL, Bailin T, Noggle S, Sadofsky MJ. A highly ordered structure in V(D)J recombination cleavage complexes is facilitated by HMG1. NUCLEIC ACIDS RESEARCH 卷: 28 期: 5 页: 1228-1236.
16. Bailin, T; Mo, XM; Sadofsky, MJ. A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination. MOLECULAR AND CELLULAR BIOLOGY 卷: 19 期: 7 页: 4664-4671
17. Mo, XM; Bailin, T; Sadofsky, MJ. RAG1 and RAG2 cooperate in specific binding to the recombination signal sequence in vitro. JOURNAL OF BIOLOGICAL CHEMISTRY 卷: 274 期: 11 页: 7025-7031
18. Muller C, Alunni-Fabbroni M, Kowenz-Leutz E, Mo XM, Tommasino M, Leutz A. Separation of C/EBP alpha-mediated proliferation arrest and differentiation pathways. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 卷: 96 期: 13 页: 7276-7281
19.Dechend R, Mo X, Schulz W, Gross M, Praus M, Dietz R, Gulba DC. Thrombin receptor and urokinase-type plasminogen activator are colocalized in vascular smooth muscle cells derived from human carotid atherosclerotic plaques. FIBRINOLYSIS 卷: 10 页: 41-45
发育遗传学和基因组学研究中心（筹）